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A meta-analysis of 80 000 patients found GLP-1 RAs were not associated with an increased risk of optic nerve/vision-threatening events [11], and a recent clinical trial of people taking the highest dose of semaglutide demonstrated excellent safety, increased muscle strength and an increased ratio of lean mass relative to total body mass in people taking semaglutide [12]
These include: A large lump under the skin that lasts for more than a few days Oozing from the injection site Ongoing pain or swelling Bleeding that is hard to stop Medication leaking out during the injection Very little or no improvement in blood sugar or weight control after many injections These signs may point to problems like injecting too shallow (into the skin) or too deep (into muscle), or using the wrong technique
Dermatologic implications of glucagon-like peptide-1 receptor agonist medications
Retatrutide, a much-hyped injection that is in the works, can apparently lead to nearly 30 percent loss in body weight on average
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