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Animal LD50 studies in mice showed approximately 320 mg per kilogram of body weight, which translates to roughly 22,400 mg for a 154-pound human
However, due to the lack of research data at present, and because the mechanism underlying the action of DPP-4iDPP-4i upon BP is complex, further studies are now needed to identify the precise mechanism involved
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The hyperreaction of mast cells when there is a normal amount in the body is known as Mast Cell Activation Syndrome (MCAS)
This would be very interesting to measure in a future study
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