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Five trials had the glycaemic efficacy assessment as the primary objective, while one trial had cardiovascular outcome as the primary objective

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Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure: The Need for Further Evidence Generation and Practice Guidelines Optimization Abstract 1,2 At present, there are an estimated 500 million patients with T2DM and 64 million with HF globally

However, this is not the typical response, and most patients have no ill effects from this supplement.