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In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions
Furthermore, lipid utilization was clearly reflected by the rapid decrease in RER in mice receiving G49
Some GLP-1 medications specifically injectable varieties also require refrigeration, much like insulin
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