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This is distinct from diabetic ketoacidosis (DKA), a dangerous condition that occurs primarily in type 1 diabetes or severe insulin deficiency
doi: 10.1210/endrev/bnaa026 68
Cross-trial comparisons are useful for a general sense of scale, not a head-to-head verdict, because the study designs and patient groups differ
Morton points to retatrutide, a weekly injection from Eli Lilly currently in clinical development for obesity and type 2 diabetes, as an example
These modifications collectively address the major limitations of natural amylin - its tendency to aggregate into toxic fibrils, rapid degradation, and poor pharmacokinetic properties - while preserving and enhancing its beneficial metabolic effects
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