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Dehydration secondary to prolonged vomiting and diarrhea represents a significant clinical concern, potentially manifesting as dizziness, decreased urine output, dry mucous membranes, tachycardia, and orthostatic hypotension

Regarding cardiovascular outcomes, the EXSCEL trial showed that exenatide extended-release was noninferior but not superior to placebo for major adverse cardiovascular events

Less Common/More Serious Concerns Higher doses or specific administration methods can lead to more significant glutathione risks

Glutathione is often called the master antioxidant because it is present in almost every cell of your body, working to neutralize free radicals and support detoxification pathways

Researchers have also continued to examine whether chronic pancreatic inflammation, recurrent pancreatitis, or prolonged pancreatic injury could contribute to long-term complications involving pancreatic cancer, although current evidence regarding causation remains under ongoing scientific review