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Endocrinology (2003) 144(11):492330
Major randomised trials of GLP-1 receptor agonists in neurodegenerative disease
Patients with PD primarily exhibit a significant loss of insulin receptor mRNA in the substantia nigra pars compacta, increased insulin IR, and reduced activation of molecules such as insulin receptor substrate 1 (IRS1) and protein kinase B (Akt) within the insulin metabolic pathway ( -synuclein accumulation
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