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Specifically, MACEs comprised myocardial infarction, stroke (either ischemic or hemorrhagic), and cardiac death, while MAKEs were defined by progression to stage 5 chronic kidney disease (CKD), end-stage kidney disease, or initiation of dialysis

The real differentiators will be sustained weight loss, discontinuation rates, gastrointestinal tolerability, long-term safety, dose escalation strategy, patient segmentation, combination rationale and benefit-risk clarity

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A proportion of infants and children with sepsis progress to cardiac failure as part of multiple system organ failure (hepatic, renal, cardiac, pulmonary) [100]