Of these three compounds the half-cell redox potential based on the ratio of GSH to oxidized glutathione (GSSG) is postulated to be a reliable marker of the intracellular redox state (Schafer and Buettner, 2001)
Why cysteine is the rate-limiting factor: The intracellular concentration of cysteine sits close to the Km value of GCL (0.1 to 0.3 mM), meaning the enzyme is operating near its saturation point under normal conditions
Reducing oxidative damage will help prevent chronic conditions like heart disease, and cancer while supporting overall cellular longevity and health
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