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It may influence: Actin binding Cell movement Endothelial cell migration New blood vessel formation Inflammation regulation Tissue remodeling Why actin matters: Actin is one of the structural proteins cells use to move, change shape, and migrate into damaged tissue

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Some patients have a threshold effect: tolerable constipation at 1.0 mg, sudden severe constipation at 1.7 mg, no further worsening at 2.4 mg

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