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Because the hydrophilicity of the drug inhibits its transport process across cell membranes, metformin must rely on transporters to actively transport in and out of cells (Hardie et al., 2012)

GLP-1 medications also seem to have relatively few side effects

The oral-contraceptive interaction is a separate study (GPGR), reported in the FDA Mounjaro NDA 215866 summary review: a single 5 mg tirzepatide dose with a combination oral contraceptive (0.035 mg ethinyl estradiol / 0.25 mg norgestimate) reduced the Cmax of norelgestromin and ethinyl estradiol by 55% to 59% a range spanning both analytes, not a separate figure for each with AUC lowered 28.8% (norelgestromin) and 27% (ethinyl estradiol), and tmax delayed 2.5 to 4.5 hours

Researchers have not conducted human studies on how safe these drugs are for nursing babies

Patients are commonly falling into disordered eating behavior because of the restrictive nature of the medications when it comes to food