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As an anti-inflammatory KPVs anti-inflammatory mechanism of action isnt fully understood, but it may have to do with a signaling pathway called NF-B

This interaction increases cell surface ATP levels, which then activates P2X4 purinergic receptors

Researchers study it for tissue repair, angiogenesis, tendon healing, and growth factor activation in laboratory models

The microbiota establishes a bi-directional communication network with the brain via neural, endocrine, and metabolic signaling modalities, hence the popular reference to the microbiome-gut-brain axis (Figure 1)

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