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Some secretion systems are widespread and secrete many different substrates in different bacterial species, whereas others are rare or exclusive to the secretion of just a few proteins

In the liver, the GSH/GSSG ratio was reduced by two-thirds and redox potential (EGSSG/2GSH) was less negative in KO mice 17

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However, its use as a therapeutic agent or in high-dose nanoformulations requires formal safety validation per drug regulatory guidelines