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Since Posss pioneering work on zebrafish heart regeneration 67 over two decades ago, researchers have identified four major signaling pathways that regulate cardiac regeneration: the Notch, HippoYAP, NRG1/ErbB/PI3K/ERK, and -catenin pathways

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Gastrointestinal Effects The most frequent adverse effects of GLP-1RAs are gastrointestinal, including nausea, vomiting, diarrhoea and a sensation of early satiety

Different ligands may trigger different conformational changes and activate different downstream signals