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The theory is that smaller, more frequent doses produce a smoother pharmacokinetic profile with less dramatic peaks in GLP-1 activity, potentially reducing the intensity of gastric emptying delay and associated reflux
Nausea is most pronounced during the initial weeks of GLP-1 treatment and typically diminishes significantly after 24 weeks as your body adapts to the medication
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Most of these side effects peak during the dose escalation phase, particularly in the first one to two weeks after each dose increase, and then gradually improve as your body adapts
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