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Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH.Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis

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Pregnant or Breastfeeding Women: The safety of these peptides during pregnancy or breastfeeding has not been established, and therefore should be avoided by these populations

Veterinary experience may provide opportunities for gathering additional safety and efficacy data that could potentially inform human applications

To be effective, your knee OA treatment protocol should include weight management, dietary modifications, lifestyle interventions, knee stabilizer strengthening, and pain management strategies that do not involve drugs or steroids