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One phase IIb clinical trial administered setmelanotide to obese participants with heterozygous MC4R deficiency and obese controls over 28 days, observing a placebo-adjusted weight loss of 2.6 kg and 4.0 kg respectively [98]
Ken Fujioka, Department of Nutrition and Metabolic Research, Scripps Clinic, La Jolla, California, and a SCALE clinical trial investigator
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Researchers continue to investigate how NNMT inhibition affects intracellular signaling, energy utilization, and the complex biochemical pathways involved in maintaining cellular homeostasis
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