A: Multiple pathways: GH receptor upregulation, nitric oxide system modulation, VEGF-promoted angiogenesis, and direct inflammatory cytokine interaction
C9orf72 mRNA sequesters a nucleocytoplasmic transport regulator in the cytoplasm, altering transport multiple RNAs and proteins through the nuclear pore [310]
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Therefore, ROS-induced immunomodulatory effects may facilitate viral replication