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Since the primary, if not exclusive, source of GLP-1 in the CSF are brainstem GLP-1 neurons (and not GLP-1 from the circulation 3 ), this suggests that CSF-contacting neurons are regulated by the overall activity of brainstem GLP-1 neurons
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Semaglutide, but not liraglutide 27 , was capable of reducing knee pain and ameliorating physical function assessed through the Western Ontario and McMaster Universities (WOMAC) scale, as shown in the individual studies (Table 4)
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