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Without uridine, the cell compensates for pyrimidine shortage by over-activating ATP-consuming salvage pathways (UCK2, TK1, dCK), which potentially drives mitochondrial biogenesis to generate more ATP for these phosphorylation reactions 63

Some people may notice changes within a few weeks, while others might take longer

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You might also find it helpful to check your gait, if you notice changes or if your shoulders or hips feel unlevelled