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The most commonly reported adverse events across all treatment arms were gastrointestinal-related, including nausea (17.4 percent [5 mg], 19.2 percent [10 mg], 22.1 percent [15 mg], 17.9 percent [semaglutide]), diarrhea (13.2 percent [5 mg], 16.4 percent [10 mg], 13.8 percent [15 mg], 11.5 percent [semaglutide]) and vomiting (5.7 percent [5 mg], 8.5 percent [10 mg], 9.8 percent [15 mg], 8.3 percent [semaglutide])
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Increased Digestive Distress Semaglutide often causes nausea, bloating, or constipation as the body adjusts to the medication
Published formulations vary one commonly cited example uses approximately 15 mg/mL methionine, 50 mg/mL choline chloride, and 50 mg/mL L-carnitine, though concentrations aren't universal across clinics or pharmacies