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The 2830 day guideline after opening reflects the point at which benzyl alcohol preservative effectiveness has declined enough that the manufacturer can no longer guarantee the bacteriostatic protection

Both Synvisc and Cortisone injections are generally safe, but they can cause temporary side effects such as pain, swelling, heat, redness, and fluid build-up around the knee

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21G-23G for intramuscular) Alcohol wipes Sharps container (usually available on prescription or via local authority schemes) Some Integrated Care Boards (ICBs) have specific policies regarding home administration, and availability may vary by region

Weeks 1 to 3: Reduced pain at rest in the injured tissue