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Vitamin D is a secosteroid hormone that has long been recognized for its functioning in regulation of calcium and phosphorus homeostasis and bone mineralization
Succinylation of PKM2 promotes its transition from a tetramer to a dimer and its entry into the nucleus, subsequently activating the NLRP3/AIM2 inflammasome and exacerbating macrophage pyroptosis and the release of inflammatory factors (IL-1, HMGB1) ( 5.3 From monitoring to remodeling: translational medicine prospects of macrophage exosomes Given the high plasticity of macrophages during the initiation and resolution phases of ARDS inflammation, transforming their exosomes from simple pathological products into clinical diagnostic and therapeutic tools represents a significant breakthrough direction in the field of critical care immunology
The results of western blot and immunofluorescence showed that knockdown of VRK2 resulted in the decline of SLC7A11 expression at PM (Fig
Tumor cells can switch from glycolysis to lipid-dependent energy production and also store excess lipids, which provides energy to support their expansion and metastasis (278)
doi: 10.3389/fnut.2020.00143 273 TeuwenL.-A.GeldhofV.PasutA.CarmelietP
