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Notably, treatments with the multi-agonists or GLP1 did not cause signs of nausea/malaise at any time-point tested (272 h), since pica behavior (i.e., kaolin intake) was similar, or even lower, in mice treated with GLP1/E, GLP1/GIP, GLP1/GIP/Glucagon, or GLP1 vs

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The tripeptide exists intracellularly either in an oxidised glutathione disulphide (GSSG) or reduced state (GSH), and maintaining an optimal GSH:GSSG ratio in the cell is critical for prevention of oxidative damage and for cell survival (Fig