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Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinsons disease occurring with type 2 diabetes in a Taiwanese population cohort

Fraser A, Tilling K, Macdonald-Wallis C, Sattar N, Brion MJ, Benfield L, et al

These biomarkers namely plasma malodialdehyde (MDA) and blood activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) are to be evaluated before and after the administration of the histamine H2 antagonist nizatidine alone or with either vitamin E (-tocopherol) or thioctic acid (-lipoic acid) or a combination of both

Animals were housed in a conventional animal facility with 12 h light/dark cycles and fed ad libitum