utilized LSKL/PLGA nanoparticles to neutralize TSP-1, significantly inhibiting the TSP-1/CD47 death receptor signaling pathway, thereby reducing mitochondrial membrane potential loss and cytochrome C release, suppressing Bax expression and Caspase-3 activation, and decreasing the TUNEL-positive rate and apoptotic cell count by 50% and 30%, respectively [86]
coli (ESBL) by targeting the enzymes involved in resistance
Flavonoids can be summarized to reverse MDR via multiple mechanisms such as regulating the ABC transporters, boosting ROS production in cancer cells, or conversely inhibiting the activities of the anti-oxidative enzymes, subduing the proliferation of cancer stem cells, inhibiting EMT (epithelialmesenchymal transition) signalling, modulating autophagy and the related factors, and lastly, by distorting the progression of cell cycle in cancer cells [202]
Medication eligibility, dosing, and duration are determined after clinical evaluation