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Spiering, B
Possible artefacts arising from the artificiality of such assays can be explored by comparing results from pseudovirus (clonal) infection of cell lines with those from authentic replicating (quasispecies) virus infection of primary cells
Nat Rev Microbiol 14 , 273287 (2016)
TB-500 is a synthetic version of a short peptide fragment from Thymosin Beta-4 , a naturally occurring protein in almost all human and animal cells
Crucially, key regulatory signaling pathways that normally bolster antioxidant defenses are also disrupted or insufficiently activated to cope with the overwhelming stress
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