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Regulatory agencies have weighed in
See the best dosage for different uses, such as lowering triglyceride levels or improving mood, plus information on overdose
Treatment length depends on the patients goal, progress, response, and side effects
Specifically, NICE suggests considering a DPP-4 inhibitor as a second agent when: The patient has a high risk of hypoglycaemia (making sulfonylureas less suitable) Weight management is a concern and a sulfonylurea's weight-gaining effects are undesirable An SGLT-2 inhibitor is contraindicated or not tolerated NICE NG28 recommends that in patients with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease, an SGLT-2 inhibitor should generally be prioritised often alongside or instead of metformin due to its organ-protective benefits
It is also virtually calorie free, with just 10% of the calories of sugar, making it a great tool for weight management
