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Pebworth, M

Though IL-6 has pro-inflammatory functions, it can also stimulate the release of IL-10 (Ostrowski et al., 1999) which in turn inhibits the production of inflammatory cytokines such as IL-1, and tumour necrosis factor- (TNF-) (Cassatella et al., 1993)

This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment

Glucoronidation There are four glucoronosyltransferases, UGT 2B15, UGT 1A1, UGT 1A6, UGT 1A9 (that we denote simply by UGT1, UGT2, UGT3, and UGT4), that glucoronidate APAP