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Wu, M.J

Key Points A small percentage of patients experience fatigue on semaglutide, often moreso with higher doses Those who do experience fatigue find it improves as their body adjusts to the medication Staying hydrated, maintaining balanced nutrition, and gradually increasing your dose can help reduce fatigue Long-term studies show that after initial side effects subside, most people actually report better energy levels as they lose weight Feeling tired while taking semaglutide (Ozempic or Wegovy)

also demonstrated that exenatide, a GLP-1 receptor agonist (RA), may suppress the expression of MMPs induced by TNF- by inhibiting the phosphorylation of components within the AKT signaling pathway 71

Delay in Gastric Emptying and Effect on Oral Drug Absorption Slowed gastric emptying may alter the absorption of oral medications