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GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

It is important to remember that not all GLP-1 medications are expressly licensed for weight loss and that the doses used for weight loss may vary from those used for managing diabetes

The biostimulatory agent stimulates your body to produce collagen and this breaks down over a period of 12-15 months

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Beyond insulation, the body's total energy expenditure typically declines with weight loss, which includes a reduction in heat production as a metabolic byproduct