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Clinical Profile of Exenatide To understand subsequent innovations, its helpful to summarize exenatides clinical profile (as the first GLP-1 RA): Efficacy: In trials, twice-daily exenatide (10 g BID) typically reduced HbAc by approximately 0.8%1.0% more than placebo by 30 weeks ( [61] ) ( [101] )

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10mg vial U-100 syringe marks 10 u=0.5 mg 20 u=1.0 mg 40 u=2.0 mg 50 u=2.5 mg Alternate: 1 ml BAC water = 10 mg/ml (10 units = 1 mg)

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Non-HDL cholesterol and apolipoprotein B may also show modest improvements, which better reflect atherogenic lipoprotein burden

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