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Furthermore, Germain et al

In these first short-term clinical trials, focused on safety and dose optimisation, the administration of two different GLP-1R/GcgR co-agonists reduced HbA 1c in overweight diabetic individuals, with some degree of body weight loss [69]

Bottom line: The additive effect of combining these two can turn manageable side effects into severe complications, particularly regarding digestion and blood sugar safety

The reluctance of health insurers is despite the predicted cost reductions due to the elimination of secondary diseases such as diabetes, knee problems, or psychological problems due to weight loss among millions of GLP 1 users