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The catalytic activity is only initiated when an association is established, in balance status, between the dimeric and tetrameric 6 forms

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Therefore, the ratio between reduced and oxidized forms of GSH is an important indicator of the redox environment and, at the same time, contributes to the accomplishment of the molecular mechanisms underlying cell proliferation, differentiation or death in the form of apoptosis (Dickinson and Forman, 2002)