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They occur during dose escalation, particularly when moving from 4mg to 8mg

Materials and Methods Animals Four weeks-old male C57BL/6 mice (Janvier Labs, Saint Berthevin, Cedex, France) were housed in a controlled environment (12 h light/dark cycle, lights on/off at 3AM/3PM

Larger Phase 3 trials are required before regulatory approval can be sought, and results in real-world clinical practice may differ from those observed under trial conditions

10.1038/nchembio.2238 39 KosyakovskyJ.FineJ

Apart from a lower appetite (which is desired in the case of weight loss), people often also experience diarrhea, nausea, and vomiting