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33 CONCLUSION While these findings are encouraging, especially for diseases such as psoriasis and HS in which patients often are heavier and may have comorbidities like type 2 diabetes, insulin resistance, or metabolic syndrome, its important to recognize that most data to date come from small observational or retrospective studies with multiple possible confounders

Chronic conditions may benefit from extended treatment periods of 3-6 months, followed by maintenance dosing or cycling protocols

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In the context of bulimia nervosa treatment, fluoxetine may help normalise eating patterns, which can also affect weight