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The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

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In a cell-free liposomeliposome contact system, iron-dependent lipid peroxidation could be transmitted between directly apposed bilayers in the absence of cytosolic signaling components, indicating that the oxidized membrane state itself can, under appropriate conditions, propagate across closely juxtaposed membranes

Am J Clin Nutr