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When ATP rises, the ATP-sensitive potassium channel in pancreatic beta cells closes, which then triggers the release of insulin.[ref] Genetic variants in KCNJ11 can decrease the beta cells insulin response to blood glucose

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In agreement with this finding, compound C also abolished the synergistic ameliorating effect of combination treatment with lower dose of metformin and liraglutide on the PA-induced reduction of p-eNOS protein level (Supplemental Fig

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