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Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
Measurements are abbreviated as milligrams (mg), pounds (lbs), and kilograms (kgs)
doi: 10.3389/fnut.2021.748075 Received 07 August 2021 Accepted 11 October 2021 Published 08 November 2021 Volume 8 - 2021 Edited by Clelia Madeddu, University of Cagliari, Italy Reviewed by Sidney B
Available: [37] B
GLP-1R agonism produces: Glucose-dependent insulin secretion (insulin released only when glucose is elevated) Suppression of glucagon secretion Delayed gastric emptying (contributing to satiety) Reduced appetite via central nervous system signalling in hypothalamic nuclei Potential cardiovascular protection (observed in clinical trials of GLP-1 agonist drugs) This receptor is the foundation of the entire GLP drug class, from exenatide to semaglutide
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