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Conversely, insufficient sleep can lead to increased appetite, impaired insulin sensitivity, and preferential loss of lean mass over fat during dieting

Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification

Dehydration from gastrointestinal side effects may cause elevated creatinine or blood urea nitrogen, necessitating hydration counseling and possible dose adjustment