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JAMA Intern Med 173:534539 Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC (2011) Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies

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Unlike insulin therapy, GLP-1 agonists stimulate insulin release only when blood sugar levels are elevated, reducing the risk of hypoglycemia

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The FDA-approved prescribing information specifies that tirzepatide should be administered once weekly on the same day each week, at any time of day, with or without meals