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Obesity contributes to this issue, as it is linked with chronic, low-grade inflammation, which correlates with conditions such as insulin resistance, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease, and atherosclerosis [10]

Avoid opening or crushing the capsule

The rate of weight loss with retatrutide was noticeably faster, with substantial reductions appearing earlier in the treatment course

Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram

Keep it away from direct light