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Increased production of melanin leads to darkening of the skin, known as hyperpigmentation

[Ref] Other Very common (10% or more): Pain (35%), flu syndrome (29%), chest pain (15%), accidental injury (12%), asthenia (12%), fever (12%) Common (1% to 10%): Peripheral edema, weight decrease, weight increase Very rare (less than 0.01%): Body odor, International Normalized Ratio (INR) increased [Ref] Local Very common (10% or more): Injection site reaction (38%) [Ref] Musculoskeletal Musculoskeletal side effects, in chronic hemodialysis patients, for levocarnitine (the active ingredient contained in L-Carnitine) in relation to placebo therapy have included asthenia (8% to 12% vs 8%) and leg cramps (4% to 8% vs 13%)

Most plant extracts and compounds associated with metabolic health do not meet these criteria

Currently Shapely serves adults age 18 and older in the states of California, Florida, New York, and Texas

This initial evaluation should also include kidney function tests, as these medications are generally avoided in patients with severe kidney dysfunction