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In rats treated with methylprednisolone, simultaneous administration of ipamorelin increased periosteal bone formation rate four-fold compared to the glucocorticoid-only group, effectively reversing the catabolic bone effects

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In liver disease, non-invasive approaches such as transient elastography, magnetic resonance elastography (MRE), and serum fibrosis panels (e.g., ELF score, Pro-C3) can be readily applied in incretin-based trials

Activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) by free fatty acid receptor 1 (FFAR1/GPR40) protects from palmitate-induced beta cell death, but plays no role in insulin secretion

It also promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue ex vivo and more profound reductions in food intake and body weight than liraglutide when administered to diet-induced obese rats