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Gradual Dosage Increase : Treatment begins with a minimal dose that is slowly increased to achieve the best balance between efficacy and tolerability
Unregulated treatment practices in mainstream use can increase complications
Brain 129, 27612772
They do not differ in the fundamental constraint: molecules above roughly 500 daltons don't cross intact stratum corneum passively, and the botanicals that do fit under that threshold arrive at doses two to three orders of magnitude below anything studied
It contains low molecular weight compounds such as the flavonoids (+)-catechin, (-)-epicatechin, (+)-taxifolin, the benzoic acids protocatechuic acid, vanillic acid, gallic acid, and the cinnamic acids ferulic acid, caffeic acid or p-coumaric acid
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