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Research has found that even before starting GLP-1 RAs, many people with obesity have inadequate intake or low blood levels of nutrients like vitamin A, vitamin C, vitamin E, calcium, magnesium, and others
In 2025, Evernorth excluded Wegovy from approximately 22% of employer plans in favor of compounded semaglutide or no coverage at all (Conklin et al., Health Affairs 2025)
Furthermore, increased TRPV2 palmitoylation in the brains of AD mice inhibits A phagocytosis in microglia, accompanied by a decrease in their phosphorylation levels, suggesting that the tyrosine phosphorylation cycle and the cysteine palmitoylation cycle have opposing effects on transient receptor potential vanilloid 2 (TRPV2) channel-mediated A phagocytosis in microglia (172)
Think of it as the difference between a vitamin C serum and an IV vitamin C push