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The more Melanin produced the greater pigmentation level becomes, making the skin progressively darker and tan lasts significantly longer

Researchers compare dose-dependent responses to establish concentration-effect relationships in these in vitro systems

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Compared with other groups, the ZFPG + US group showed the strongest cancer cell necrosis and apoptosis, as well as the lowest Ki-67 expression, suggesting that ZFPG + US treatment could inhibit cancer cell proliferation and induce cell apoptosis to improve the anti-tumor effect