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Diabetes Care 35, 12251231
To further test the extent of this and specifically whether metformin's activity extended to the brain the researchers used a mouse model, breeding mice that had been genetically modified to lack the protein Rap1 in a part of the brain called the ventromedial nucleus of the hypothalamus (VMH)
Yes, it can happen, but its far from the end of the road
These drugs are prescribed in patients who are unresponsive to metformin due to contraindications or intolerance
In addition, the glutathione taken from food is absorbed less effectively in old age
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