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in men spontaneous erections , in women increased sexual desire Modulation of the reward system in the brain PT-141 (Bremelanotide) is an MC4R-selective derivative optimized precisely for this sexual effect (with minimal cutaneous and metabolic side effects)
Studies show it can reduce fat mass, support lean muscle, and improve heart muscle function when deficiency is present
For example, in 2015, a randomized clinical trial of elderly men with sarcopenia found that 15g of daily collagen peptide supplementation, in combination with resistance training, led to improvements in multiple parameters: muscle strength, fat mass, and fat-free mass.40 For another example, a 2023 study of subjects with ultrasound-confirmed musculoskeletal inflammation concluded that locally injected collagen peptides could effectively and safely treat collateral ligament pain, indicating positive implications for physical recovery.41 It isnt clear how collagen compares to other peptides in facilitating these outcomes, as head-to-head studies arent available
GIP is a metabolic hormone that promotes insulin secretion and also weakly inhibits gastric acid secretion to suppress appetite
Tirzepatide appears to have a greater effect on glycemic control but retatrutide trials are still limited
