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doi: 10.1172/JCI169922 71 KirklandJTchkoniaT
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The two compounds represent distinct mechanistic approaches to metabolic research and are not directly interchangeable in protocol design
IGF-1 exerts its actions on a cellular level via the IGF-1 receptor (IGF-1R) which results in activation of several intracellular pathways, including the ERK1/2 and phosphatidylinositol 3-kinase/AKT pathways
2 Other plant forms (bark, seeds, and flesh) can also lead to toxic amounts
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